Gdp E248 (2024)

1. Involvement of the Penta-EF-Hand Protein Pef1p in the Ca2+- ... - PLOS

Arrows indicate the critical calcium interacting residues E180, E181, and E248. ... Transition of Sar1p from the GTP-bound to the GDP-bound state was monitored by ...
Although it is well established that the coat protein complex II (COPII) mediates the transport of proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus, the regulation of the vesicular transport event and the mechanisms that act to counterbalance the vesicle flow between the ER and Golgi are poorly understood. In this study, we present data indicating that the penta-EF-hand Ca2+-binding protein Pef1p directly interacts with the COPII coat subunit Sec31p and regulates COPII assembly in Saccharomyces cerevisiae. ALG-2, a mammalian hom*olog of Pef1p, has been shown to interact with Sec31A in a Ca2+-dependent manner and to have a role in stabilizing the association of the Sec13/31 complex with the membrane. However, Pef1p displayed reversed Ca2+ dependence for Sec13/31p association; only the Ca2+-free form of Pef1p bound to the Sec13/31p complex. In addition, the influence on COPII coat assembly also appeared to be reversed; Pef1p binding acted as a kinetic inhibitor to delay Sec13/31p recruitment. Our results provide further evidence for a linkage between Ca2+-dependent signaling and ER-to-Golgi trafficking, but its mechanism of action in yeast seems to be different from the mechanism reported for its mammalian hom*olog ALG-2.

Serving as a measure for Turkey's external demand, the export-weighted global production index has indicated worse prospects than the GDP-weighted index, which ...

2010 Aug; 299(2): E241–E248. Published online ... Once the GTP bound to eIF2 is hydrolyzed to GDP (a step ... The rate of exchange of [3H]GDP for unlabeled GDP ...
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... GDP, real wages and the real return to capital ... e248-4dc9-aac8-f, Tilburg University, School of ... e248-4dc9-aac8-f, Tilburg University, School of ...
We argue that paygo rates are determined by a representative agent and a benevolent government jointly maximizing the expected life-time utility of the agent. The distributions of labor and capital in

June 2016 was 12.2 percent of GDP. ... content/083a15cc-e248-11e6-9645-c9357a75844a. 14 ... 53 Mohamed Hamama, “Sisi Says Military Economy is 1.5% of Egypt's GDP, ...

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